Relationship of Cx-reactive Protein Response to Induction of Liver and Kidney Catatases following Hematin Administration into Rabbits
نویسندگان
چکیده
The relationship of rabbit Cx-reactive protein (CxRP) and the enzymatic activity of hepatic and kidney catalases in rabbits following i.v. hematin administration has been examined sequentially. The early increases in rab bit liver and kidney catalatic activities were accompanied by the corresponding decreases in ßCxRP and an early appearance of 7 CxRP after hematin administration. Immunoelectrophoretic analysis of serum samples revealed two types of CxRP: a preexisting, although variable in concentration, ßCxRP and a 7 CxRP which appeared within 3 hr and then disappeared after 24 hr following a single injection of hematin. Adjuvant-treated rabbits showed slight depression of liver catalase with an in crease in ßand 7 CxRP levels. When hematin was ad ministered to these animals, a rise in both liver and kidney catalases ensued with a concomitant decrease in serum ßand 7 CxRP's 3 hr after hematin. Actinomycin
منابع مشابه
Relationship of Cx-reactive protein response to induction of liver and kidney catalases following hematin administration into rabbits.
The relationship of rabbit Cx-reactive protein (CxRP) and the enzymatic activity of hepatic and kidney catalases in rabbits following i.v. hematin administration has been examined sequentially. The early increases in rab bit liver and kidney catalatic activities were accompanied by the corresponding decreases in ßCxRP and an early appearance of 7 CxRP after hematin administration. Immunoelectr...
متن کاملThe Relationship between the Acute Phase Response and Antibody Production in the Rabbit
It has been found that some rabbits respond to the administration of either human C-reactive protein or human gamma globulin with the production of an acute phase substance, Cx-reactive protein. A correlation was found to exist between the amount of Cx-protein produced and the subsequent production of significant titers of precipitating antibody to the two antigens employed.
متن کاملTHE RELATIONSHIP BETWEEN THE ACUTE PHASE RESPONSE AND ANTIBODY PRODUCTION IN THE RABBIT II. THE STm-t~LATION OF CX-REACTIVE PROTEIN RESPONSE BY CERTAIN ADJUVANTS AND THE RELATION OF THIS RESPONSE TO THE ENHANCE- MENT OF ANTIBODY FORMATION
In the preceding paper it has been shown that a correlation exists between the production of Cx-reactive protein by rabbits in response to the administration of the two antigens, human C-reactive protein and human gamma globulin, and the subsequent production of precipitating antibody in high titer (1, 2). This finding suggested that it would be of interest to investigate the effects of an adju...
متن کاملBiochemical and Histopathological study of Mesobuthus eupeus scorpion venom in the experimental rabbits
In tropical and subtropical countries, envenomation by scorpions (so-called scorpionism) represents a serious public health problem. In the present study, the toxic effects of mice LD50 injections of Mesobuthus eupeus (Me) venom on the kidney and liver of anesthetized rabbits were investigated. Six rabbits were selected and ALT, AST, BUN and creatinine were measured at 0, 1 and 3 hours after...
متن کاملبررسی اثرات محافظتی اداراون بر کاهش سمیت کلیوی و عصبی ناشی از مواجهه حاد با دیازینون
Background and purpose: Diazinon (Dz) is a widely used insecticide. It can cause nephrotoxicity and neurotoxicity by induction of oxidative stress. Edaravone is a drug with antioxidant effect that is used in treatment of acute infraction disorders. In this study we used edaravone for ameliorating diazinon induced kidney and brain damage. Materials and methods: Twenty four male Wistar rats were...
متن کامل